A role of plasminogen in atherosclerosis and restenosis models in mice.

@article{Plow1999ARO,
  title={A role of plasminogen in atherosclerosis and restenosis models in mice.},
  author={Edward F Plow and Victoria A. Ploplis and Steven Busuttil and Peter Carmeliet and D{\'e}sir{\'e} Collen},
  journal={Thrombosis and haemostasis},
  year={1999},
  volume={82 Suppl 1},
  pages={4-7}
}
In addition to its preeminent role in fibrinolysis, the plasminogen system is believed to play a key role in mediating cell migration. Leukocyte migration into the vessel wall is a key and early event in the development of the lesions of atherosclerosis and restenosis, pathologies which may be viewed as specific examples of vascular inflammatory responses. The development of mice in which the plasminogen gene has been inactivated affords an opportunity to test the contribution of plasminogen in… CONTINUE READING

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