A role of periaqueductal grey NR2B-containing NMDA receptor in mediating persistent inflammatory pain

@inproceedings{Hu2009ARO,
  title={A role of periaqueductal grey NR2B-containing NMDA receptor in mediating persistent inflammatory pain},
  author={Jing Fang Hu and Zhe Wang and Yan-yan Guo and Xiao-Nan Zhang and Zhao-hui Xu and Shui-Bing Liu and Hong-ju Guo and Qi Yang and Feng Xiaoguang Zhang and Xiao-li Sun and Minggao Zhao},
  booktitle={Molecular pain},
  year={2009}
}
The midbrain periaqueductal grey (PAG) is a structure known for its roles in pain transmission and modulation. Noxious stimuli potentiate the glutamate synaptic transmission and enhance glutamate NMDA receptor expression in the PAG. However, little is known about roles of NMDA receptor subunits in the PAG in processing the persistent inflammatory pain. The present study was undertaken to investigate NR2A- and NR2B-containing NMDA receptors in the PAG and their modulation to the peripheral… CONTINUE READING

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