A role of p44/42 mitogen‐activated protein kinases in formylpeptide receptor‐mediated phospholipase D activity and oxidant production

@article{Paruch2006ARO,
  title={A role of p44/42 mitogen‐activated protein kinases in formylpeptide receptor‐mediated phospholipase D activity and oxidant production},
  author={Sylvain Paruch and Jamel El-Benna and Bahia Djerdjouri and Stefano Marullo and Axel Périanin},
  journal={The FASEB Journal},
  year={2006},
  volume={20}
}
Phosphatidylcholine‐specific phospholipase D (PLD) is a major cellular source of phosphatidic acid and choline, which regulate various physiopathological processes. PLD activation mediated by chemoattractants involves protein phosphorylation. This study provides pharmacological and biochemical evidence of a major role of p44/42 MAP kinases (ERK1/2) in PLD activation induced by the chemotactic peptide N‐formyl‐methionyl‐leucyl‐phenylalanine (fMLP). ERK1/2 inhibition by the MEK1/2 antagonist… 

Protein Kinase B (AKT) Mediates Phospholipase D Activation via ERK1/2 and Promotes Respiratory Burst Parameters in Formylpeptide-stimulated Neutrophil-like HL-60 Cells*

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CCR5 signaling through phospholipase D involves p44/42 MAP‐kinases and promotes HIV‐1 LTR‐directed gene expression

PLD is activated downstream of ERK1/2 upon CCR5 activation and plays a major role in promoting HIV‐1 LTR transactivation and virus replication' which may open novel perspectives to anti‐HIV‐1 strategies.

Gi-Dependent Cell Signaling Responses of the Human P2Y14 Receptor in Model Cell Systems

Results illustrate that the human P2y14-R signals through Gi to inhibit adenylyl cyclase, and P2Y14- R activation also leads to ERK1/2 activation.

Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways Published, JLR Papers in Press, July 3, 2007.

A working model is proposed for S1P in which stimulation of the PI3K/PKB and MEK/ERK pathways leads to the stimulation of PLD and aldosterone secretion.

Phospholipase D1 Plays a Key Role in TNF-α Signaling1

The critical role of PLD1 in the intracellular signaling cascades initiated by TNF-α and its functional role for coordinating the signals to inflammatory responses is demonstrated.

Intracellular Signaling Pathways Regulating Hepatic Apolipoprotein B100 Production: Roles of Mitogen-activated Protein Kinases (MAPKs) and Inhibitor of NFkappaB Kinase (IKK)-NFkappaB

The results suggest that among the MAPK cascades, the MEK-ERK pathway is crucial in regulating apoBlipoprotein assembly, possibly by modulating lipid availability to newly-synthesized apoB.

fMLP induces Hsp27 expression, attenuates NF-kappaB activation, and confers intestinal epithelial cell protection.

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