A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation.

@article{Li2009ARO,
  title={A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation.},
  author={Yajuan Li and Shuang Liu and Fengmin Lu and Ting Zhang and Hairu Chen and Songwei Wu and Hui Sheng Zhuang},
  journal={Oncology reports},
  year={2009},
  volume={22 5},
  pages={1229-35}
}
The role of T-type Ca2+ channels in hepatocellular carcinoma cell proliferation was investigated in vitro. Eleven hepatocellular carcinoma cell lines and one immortalized liver cell line (LO2) were examined for the status of T-type Ca2+ channels with RT-PCR and voltage-clamp recordings. Except HBxF344, other cell lines tested had one, two or all three of alpha1-subunits (alpha1G, alpha1H and alpha1I) mRNA expression. Obvious T-type current was recorded in SNU449 cells, while others exhibited a… CONTINUE READING
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