A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.

  title={A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.},
  author={R F Wang and Cuiling Li and Xiaoling Xu and Yin Zheng and Cuiying Xiao and Patricia M. Zerfas and Sharon S. Cooperman and Michael W Eckhaus and Tracey Rouault and Lopa Mishra and Chu-xia Deng},
  journal={Cell metabolism},
  volume={2 6},
Hereditary hemochromatosis, characterized by iron overload in multiple organs, is one of the most common genetic disorders among Caucasians. Hepcidin, which is synthesized in the liver, plays important roles in iron overload syndromes. Here, we show that a Cre-loxP-mediated liver-specific disruption of SMAD4 results in markedly decreased hepcidin expression and accumulation of iron in many organs, which is most pronounced in liver, kidney, and pancreas. Transcript levels of genes involved in… CONTINUE READING
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