A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity.

@article{Kanevets2009ARO,
  title={A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity.},
  author={Uliana Kanevets and Karan Sharma and Karen Dresser and Yan Shi},
  journal={Journal of immunology},
  year={2009},
  volume={182 4},
  pages={1912-8}
}
Uric acid is released from injured cells and can act as an adjuvant signal to the immune system. Uric acid crystals invoke strong inflammatory responses in tissues. Although their biological effects are evident and the associated signaling mechanisms are becoming clear, it remains unexplained as to why uric acid precipitates rapidly in vivo, in sharp… CONTINUE READING