A role in enzyme activation for the N-terminal leader sequence in calmodulin.

@article{Persechini1996ARI,
  title={A role in enzyme activation for the N-terminal leader sequence in calmodulin.},
  author={Anthony Persechini and K J Gansz and Robert J. Paresi},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 32},
  pages={19279-82}
}
We have found that deletion of residues 2-8 from the N-terminal leader sequence: Ala1-Asp2-Gln-Leu4-Thr-Glu6-Glu-Gln8, in calmodulin abolishes calmodulin-dependent activation of skeletal muscle myosin light chain kinase activity and reduces calmodulin-dependent activation of smooth muscle myosin light chain kinase activity to approximately 50% of the maximum level measured at a saturating calmodulin concentration. Calmodulin-dependent activation of cerebellar nitric oxide synthase activity is… CONTINUE READING