A role for tyrosinase-related protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes: Implications for vitiligo.

@article{Manga2006ARF,
  title={A role for tyrosinase-related protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes: Implications for vitiligo.},
  author={Prashiela Manga and David Sheyn and Fan Yang and Rangaprasad Sarangarajan and Raymond E. Boissy},
  journal={The American journal of pathology},
  year={2006},
  volume={169 5},
  pages={1652-62}
}
Vitiligo presents with depigmented cutaneous lesions following localized melanocyte death. Multiple factors contribute to cell death, including genetically determined susceptibility to trauma, and environmental factors, such as exposure to 4-tert-butylphenol (4-TBP). We demonstrate that 4-TBP induces oxidative stress that is more readily overcome by melanocytes from normally pigmented individuals than from two individuals with vitiligo. The antioxidant catalase selectively and significantly… CONTINUE READING
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