A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB.

@article{Mirza1997ARF,
  title={A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB.},
  author={Ayoub Mirza and S. L. Liu and E R Frizell and Jianling Zhu and S Maddukuri and Jean Mart{\'i}nez and Paul Sheldon Davies and Roland S Schwarting and Pamela A Norton and Mark A. Zern},
  journal={The American journal of physiology},
  year={1997},
  volume={272 2 Pt 1},
  pages={G281-8}
}
This study was undertaken to delineate a possible role for tissue transglutaminase (tTG), an enzyme that catalyzes protein cross-linking, in hepatic fibrogenesis. Rats were treated with CCl4 solution and then killed at different stages of liver injury and fibrogenesis. Liver tTG mRNA levels were markedly increased as early as 6 h after the first injection, peaked at 4 days and 1 wk, and remained increased for 8 wk. The enzymatic activity of tTG was increased in livers of rats treated with CCl4… CONTINUE READING

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