A role for thrombin in the initiation of the immune response to therapeutic factor VIII.


Administration of human factor VIII (FVIII) to FVIII knockout hemophilia mice is a useful small animal model to study the physiologic response in patients iatrogenically immunized to this therapeutic protein. These mice manifest a robust, T cell-dependent, antibody response to exogenous FVIII treatment, even when encountered through traditionally… (More)
DOI: 10.1182/blood-2008-10-186452


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