A role for the proteasome regulator PA28alpha in antigen presentation.

  title={A role for the proteasome regulator PA28alpha in antigen presentation.},
  author={Marcus Groettrup and Andrea Soza and Maren Eggers and Lothar Kuehn and Tobias P Dick and Hansjoerg Schild and Hans Georg Rammensee and Ulrich Koszinowski and Peter Michael Kloetzel},
  volume={381 6578},
Cytotoxic T cells recognize viral proteins as peptide fragments which are produced in the cytosol and transported on major histocompatibility complex (MHC) class I proteins to the cell surface. Viral peptides that meet the stringent binding characteristics of class I proteins are generated by the 20S proteasome. The interferon (IFN)-gamma-inducible activator of the 20S proteasome, PA28, strongly influences the proteasomal cleavage pattern in vitro. This led us to investigate whether changes in… CONTINUE READING


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