A role for the proteasome in the light response of the timeless clock protein.

@article{Naidoo1999ARF,
  title={A role for the proteasome in the light response of the timeless clock protein.},
  author={N. Naidoo and W. Song and M. Hunter-Ensor and A. Sehgal},
  journal={Science},
  year={1999},
  volume={285 5434},
  pages={
          1737-41
        }
}
The cyclic expression of the period (PER) and timeless (TIM) proteins is critical for the molecular circadian feedback loop in Drosophila. The entrainment by light of the circadian clock is mediated by a reduction in TIM levels. To elucidate the mechanism of this process, the sensitivity of TIM regulation by light was tested in an in vitro assay with inhibitors of candidate proteolytic pathways. The data suggested that TIM is degraded through a ubiquitin-proteasome mechanism. In addition, in… Expand
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