A role for the pregnane X receptor in flucloxacillin-induced liver injury.

  title={A role for the pregnane X receptor in flucloxacillin-induced liver injury.},
  author={Elise Andrews and Martin Armstrong and Jonathan D. Tugwood and D Swan and Philip D Glaves and Munir Pirmohamed and Guruprasad P Aithal and Matthew C. Wright and Christopher Paul Day and Ann K Daly},
  volume={51 5},
UNLABELLED Drug-induced liver injury (DILI) due to flucloxacillin is a rare but serious complication of treatment. There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist. This study was designed to investigate the relevance of PXR to flucloxacillin toxicity and to identify genes changing in expression in response to flucloxacillin. Changes in gene expression in human hepatocytes after treatment with 500 microM flucloxacillin for 72 hours were examined by… CONTINUE READING
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Drug-induced cholestasis. In: Farrell GC, ed. DrugInduced Liver Disease

  • GC Farrell
  • 1994
Highly Influential
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