A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini.

@article{Schaefer1998ARF,
  title={A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini.},
  author={Claus Schaefer and Sarah E. Ross and M Julia Bragado and Guy E. Groblewski and Stephen A. Ernst and John A. Williams},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 37},
  pages={24173-80}
}
Cholecystokinin (CCK) and other pancreatic secretagogues have recently been shown to activate signaling kinase cascades in pancreatic acinar cells, leading to the activation of extracellular signal-regulated kinases and Jun N-terminal kinases. We now show the presence of a third kinase cascade activating p38 mitogen-activated protein (MAP) kinase in isolated rat pancreatic acini. CCK and osmotic stress induced by sorbitol activated p38 MAP kinase within minutes; their effects were dose… CONTINUE READING

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