A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.

  title={A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.},
  author={John C. Schell and Kristofor A Olson and Lei Jiang and Amy J. Hawkins and Jonathan G Van Vranken and Jianxin Xie and Robert A. Egnatchik and Espen G Earl and Ralph J DeBerardinis and Jared Rutter},
  journal={Molecular cell},
  volume={56 3},
Cancer cells are typically subject to profound metabolic alterations, including the Warburg effect wherein cancer cells oxidize a decreased fraction of the pyruvate generated from glycolysis. We show herein that the mitochondrial pyruvate carrier (MPC), composed of the products of the MPC1 and MPC2 genes, modulates fractional pyruvate oxidation. MPC1 is deleted or underexpressed in multiple cancers and correlates with poor prognosis. Cancer cells re-expressing MPC1 and MPC2 display increased… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 61 extracted citations

The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?

Biochimica et biophysica acta • 2016
View 4 Excerpts
Highly Influenced

C-Terminal Binding Protein 1 Modulates Cellular Redox via Feedback Regulation of MPC1 and MPC2 in Melanoma Cells

Medical science monitor : international medical journal of experimental and clinical research • 2018
View 3 Excerpts


Publications referenced by this paper.
Showing 1-10 of 83 references

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.

The Journal of biological chemistry • 2008
View 14 Excerpts
Highly Influenced

A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth, Molecular Cell


Metabolic requirements for the maintenance of self-renewing stem cells

Nature Reviews Molecular Cell Biology • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…