A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.

@article{Schell2014ARF,
  title={A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.},
  author={John C. Schell and Kristofor A Olson and Lei Jiang and Amy J. Hawkins and Jonathan G Van Vranken and Jianxin Xie and Robert A. Egnatchik and Espen G Earl and Ralph J DeBerardinis and Jared Rutter},
  journal={Molecular cell},
  year={2014},
  volume={56 3},
  pages={400-13}
}
Cancer cells are typically subject to profound metabolic alterations, including the Warburg effect wherein cancer cells oxidize a decreased fraction of the pyruvate generated from glycolysis. We show herein that the mitochondrial pyruvate carrier (MPC), composed of the products of the MPC1 and MPC2 genes, modulates fractional pyruvate oxidation. MPC1 is deleted or underexpressed in multiple cancers and correlates with poor prognosis. Cancer cells re-expressing MPC1 and MPC2 display increased… CONTINUE READING

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