A role for the exosome in the in vivo degradation of unstable mRNAs.

@article{Haile2003ARF,
  title={A role for the exosome in the in vivo degradation of unstable mRNAs.},
  author={Simon Haile and Antonio Est{\'e}vez and Christine Clayton},
  journal={RNA},
  year={2003},
  volume={9 12},
  pages={1491-501}
}
In mammals, the mRNAs encoding many proteins involved in inflammation bear destabilizing AU-rich elements (AREs) in the 3'-untranslated region. The exosome, a complex of 3' --> 5' exonucleases, is rate limiting in the destruction of such mRNAs in a mammalian in vitro system, but a role in vivo has not been demonstrated. The phenomenon of ARE-mediated degradation also occurs in the protist parasite Trypanosoma brucei. Messenger RNAs with 3'-untranslated region U-rich elements, which strongly… CONTINUE READING
27 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…