A role for the endocrine and pro-inflammatory mediator MIF in the control of insulin secretion during stress.

@article{Waeber1999ARF,
  title={A role for the endocrine and pro-inflammatory mediator MIF in the control of insulin secretion during stress.},
  author={G{\'e}rard Waeber and Thierry Calandra and Christophe Bonny and Richard Bucala},
  journal={Diabetes/metabolism research and reviews},
  year={1999},
  volume={15 1},
  pages={47-54}
}
The systemic response to injury or infection is often accompanied by significant alterations in host metabolism and glucose homeostasis. Within the liver, these changes include a decrease in glycogenesis and an increase in gluconeogenesis, and in peripheral tissues, the development of insulin resistance and the increased utilization of glucose by non-insulin-dependent pathways. Depending on the severity and the duration of the response, both hyper- and hypoglycemia can ensue and each can become… CONTINUE READING
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