A role for the cystic fibrosis transmembrane conductance regulator in the nitric oxide-dependent release of Cl- from acidic organelles in amacrine cells.

@article{Krishnan2017ARF,
  title={A role for the cystic fibrosis transmembrane conductance regulator in the nitric oxide-dependent release of Cl- from acidic organelles in amacrine cells.},
  author={Vijai S. Krishnan and J Wesley Maddox and Tyler Rodriguez and Evanna Gleason},
  journal={Journal of neurophysiology},
  year={2017},
  volume={118 5},
  pages={
          2842-2852
        }
}
γ-Amino butyric acid (GABA) and glycine typically mediate synaptic inhibition because their ligand-gated ion channels support the influx of Cl- However, the electrochemical gradient for Cl- across the postsynaptic plasma membrane determines the voltage response of the postsynaptic cell. Typically, low cytosolic Cl- levels support inhibition, whereas higher levels of cytosolic Cl- can suppress inhibition or promote depolarization. We previously reported that nitric oxide (NO) releases Cl- from… CONTINUE READING
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