A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.

@article{Arai2005ARF,
  title={A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.},
  author={Satoko Arai and John M Shelton and Mingyi Chen and Michelle N. Bradley and A. Hern{\'a}ndez Castrillo and Angie L. Bookout and Puiying A. Mak and Peter A. Edwards and David J Mangelsdorf and Peter Tontonoz and Toru Miyazaki},
  journal={Cell metabolism},
  year={2005},
  volume={1 3},
  pages={201-13}
}
Macrophages play a central role in the development of atherosclerosis through the accumulation of oxidized LDL (oxLDL). AIM (Spalpha/Api6) has previously been shown to promote macrophage survival; however, its function in atherogenesis is unknown. Here we identify AIM as a critical factor that protects macrophages from the apoptotic effects of oxidized lipids. AIM protein is induced in response to oxLDL loading and is highly expressed in foam cells within atherosclerotic lesions. Interestingly… CONTINUE READING

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