A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets.

@article{Rosado2000ARF,
  title={A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets.},
  author={Juan Antonio Rosado and Stewart O. Sage},
  journal={Trends in cardiovascular medicine},
  year={2000},
  volume={10 8},
  pages={327-32}
}
Store-mediated Ca(2+) entry (SMCE) is a major pathway for Ca(2+) influx in many cells, yet how depletion of the intracellular Ca(2+) stores leads to the activation of Ca(2+) entry across the plasma membrane is not well understood. Recent work in platelets favors a secretion-like conformational coupling mechanism involving proteins in the plasma membrane (PM) and in the membrane of the Ca(2+) store, located in the endoplasmic reticulum (ER). The activation and maintenance of SMCE in platelets… CONTINUE READING

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