A role for the Warburg effect in preimplantation embryo development: metabolic modification to support rapid cell proliferation.

@article{Krisher2012ARF,
  title={A role for the Warburg effect in preimplantation embryo development: metabolic modification to support rapid cell proliferation.},
  author={Rebecca L. Krisher and Randall S Prather},
  journal={Molecular reproduction and development},
  year={2012},
  volume={79 5},
  pages={311-20}
}
In this essay, we propose that embryos express a metabolic phenotype necessarily different from that of differentiated somatic cells and more like that of rapidly proliferating cancer cells. This metabolic adaptation, known as the Warburg effect, supports rapid cell proliferation. One of the hallmarks of the Warburg effect is that pyruvate is directed away… CONTINUE READING