A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

@article{Sun2005ARF,
  title={A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.},
  author={Yingli Sun and Xiaofeng Jiang and Shujuan Chen and Norvin D Fernandes and Brendan D. Price},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 37},
  pages={13182-7}
}
The ataxia telangiectasia mutant (ATM) protein kinase regulates the cell's response to DNA damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA repair. However, the signal-transduction pathway linking DNA strand breaks to activation of ATM's kinase activity is not clearly defined. Here, we demonstrate that DNA damage induces the rapid acetylation of ATM. This acetylation depends on the Tip60 histone acetyltransferase (HAT). Suppression of Tip60 blocks the… CONTINUE READING
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