A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II

@article{Hutten2014ARF,
  title={A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II},
  author={Saskia Hutten and G. Chachami and U. Winter and F. Melchior and A. Lamond},
  journal={Journal of Cell Science},
  year={2014},
  volume={127},
  pages={1065 - 1078}
}
  • Saskia Hutten, G. Chachami, +2 authors A. Lamond
  • Published 2014
  • Biology, Medicine
  • Journal of Cell Science
  • ABSTRACT Cajal bodies are nuclear structures that are involved in biogenesis of snRNPs and snoRNPs, maintenance of telomeres and processing of histone mRNA. Recently, the SUMO isopeptidase USPL1 was identified as a component of Cajal bodies that is essential for cellular growth and Cajal body integrity. However, a cellular function for USPL1 is so far unknown. Here, we use RNAi-mediated knockdown in human cells in combination with biochemical and fluorescence microscopy approaches to… CONTINUE READING
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