A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats
@article{Erb2001ARF, title={A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats}, author={Suzanne M. Erb and Natalina Salmaso and Demetra Rodaros and Jane Stewart}, journal={Psychopharmacology}, year={2001}, volume={158}, pages={360-365} }
Abstract. Rationale: We reported previously that bilateral injection of a corticotropin-releasing factor (CRF)-receptor antagonist, D-Phe CRF12–41, into the bed nucleus of the stria terminalis (BNST) blocks the reinstatement of cocaine seeking induced by footshock, whereas the injection of CRF into the same region induces reinstatement. One source of CRF in the BNST arises from a CRF-containing projection originating in the central nucleus of the amygdala (CeA). Objective: To determine whether…
306 Citations
Blockade of Stress-Induced But Not Cocaine-Induced Reinstatement by Infusion of Noradrenergic Antagonists into the Bed Nucleus of the Stria Terminalis or the Central Nucleus of the Amygdala
- Biology, PsychologyThe Journal of Neuroscience
- 2002
The data suggest that stress-induced NA activation in the BNST and in the region of the CeA is critical to relapse to drug seeking induced by stress but not to relapse induced by priming injections of cocaine, and it is hypothesized that NA activity leads to activation of corticotropin-releasing factor neurons in these regions.
Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats
- Biology, PsychologyPsychopharmacology
- 2005
The present results demonstrate dissociable roles of CRF1 receptors in the BNST, amygdala, and NAc in footshock-stress- vs morphine-priming-induced reinstatement of drug CPP.
Beta-2 adrenergic receptors mediate stress-evoked reinstatement of cocaine-induced conditioned place preference and increases in CRF mRNA in the bed nucleus of the stria terminalis in mice
- Biology, PsychologyPsychopharmacology
- 2014
Findings indicate that, during stress, norepinephrine, via β2-ARs, either directly or indirectly activates CRF-releasing neurons in the BNST that interface with motivational neurocircuitry to induce reinstatement of cocaine-conditioned reward.
Cocaine pre-exposure enhances CRF-induced expression of c-fos mRNA in the central nucleus of the amygdala: An effect that parallels the effects of cocaine pre-exposure on CRF-induced locomotor activity
- Biology, PsychologyNeuroscience Letters
- 2005
Stress-Induced Cocaine Seeking Requires a Beta-2 Adrenergic Receptor-Regulated Pathway from the Ventral Bed Nucleus of the Stria Terminalis That Regulates CRF Actions in the Ventral Tegmental Area
- Biology, PsychologyThe Journal of Neuroscience
- 2014
It is demonstrated that, in the vBNST, corticotropin releasing factor is expressed in neurons that innervate the ventral tegmental area (VTA), a site where the CRF receptor antagonist antalarmin prevents the reinstatement of cocaine seeking by a stressor, intermittent footshock, following intravenous self-administration in rats.
Effects of lidocaine-induced inactivation of the bed nucleus of the stria terminalis, the central or the basolateral nucleus of the amygdala on the opponent-process actions of self-administered cocaine in rats
- Psychology, BiologyPsychopharmacology
- 2011
These data suggest that the BNST and to a lesser extent the CeA, but not the BLA, play a role in mediating the opponent-process actions of self-administered cocaine.
A Study of Corticotropin-releasing Factor-catecholamine Interactions in the Reinstatement of Cocaine Seeking in Rats
- Biology, Psychology
- 2012
Findings suggest a functional interaction between NA and CRF systems in mediating stress-induced reinstatement of cocaine seeking, whereby activation of CRF receptors occurs subsequent to, and downstream of, the sites of action of NA.
Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats
- Psychology, BiologyPsychopharmacology
- 2004
The functional integrity of the Nacc, but not the NACs, is necessary for conditioned cue-induced reinstatement of cocaine seeking behavior.
Involvement of central amygdalar and bed nucleus of the stria terminalis corticotropin-releasing factor in behavioral responses to social defeat.
- Biology, PsychologyBehavioral neuroscience
- 2004
Data suggest that CRF acts within a neural circuit that includes the amygdala and the BNST to modulate agonistic behavior following social defeat, and is a critical component of the neural circuitry mediating conditioned defeat.
Effect of blockade of corticotropin-releasing factor receptors in the median raphe nucleus on stress-induced c-fos mRNA in the rat brain
- Biology, PsychologyNeuroscience
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