A role for the C3a anaphylatoxin receptor in the effector phase of asthma

@article{Humbles2000ARF,
  title={A role for the C3a anaphylatoxin receptor in the effector phase of asthma},
  author={Alison A. Humbles and Bao Shi Lu and Christy A. Nilsson and C. Joseph Lilly and Helene M Langevin and Yuko Fujiwara and Norma P. Gerard and Craig Gerard},
  journal={Nature},
  year={2000},
  volume={406},
  pages={998-1001}
}
Asthma is a chronic inflammatory disease of the airways and lung mucosa with a strong correlation to atopy and acquired (IgE) immunity. However, many features of bronchial asthma, such as smooth muscle contraction, mucus secretion and recruitment of inflammatory cells, are consistent with the actions of complement anaphylatoxins, in particular C3a and C5a. Complement activation forms a central core of innate immune defence against mucosal bacteria, viruses, fungi, helminths and other pathogens… CONTINUE READING