A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

@article{Brash1991ARF,
  title={A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.},
  author={Douglas E. Brash and Jeffrey A. Rudolph and Julian A Simon and A Lin and G J Mckenna and Howard P. Baden and Alan J Halperin and Jan Pont{\'e}n},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 22},
  pages={10124-8}
}
Sunlight is a carcinogen to which everyone is exposed. Its UV component is the major epidemiologic risk factor for squamous cell carcinoma of the skin. Of the multiple steps in tumor progression, those that are sunlight-related would be revealed if they contained mutations specific to UV. In a series of New England and Swedish patients, we find that 14/24 (58%) of invasive squamous cell carcinomas of the skin contain mutations in the p53 tumor suppressor gene, each altering the amino acid… CONTINUE READING