A role for sorting nexin 27 in AMPA receptor trafficking

@inproceedings{Loo2014ARF,
  title={A role for sorting nexin 27 in AMPA receptor trafficking},
  author={Li Shen Loo and Ning Tang and Muthafar Al-Haddawi and Gavin Stewart Dawe and Wanjin Hong},
  booktitle={Nature communications},
  year={2014}
}
Sorting nexin 27 (SNX27), a PDZ domain-containing endosomal protein, was recently shown to modulate glutamate receptor recycling in Down's syndrome. However, the precise molecular role of SNX27 in GluA1 trafficking is unclear. Here we report that SNX27 is enriched in dendrites and spines, along with recycling endosomes. Significantly, the mobilization of SNX27 along with recycling endosomes into spines was observed. Mechanistically, SNX27 interacts with K-ras GTPase via the RA domain; and… CONTINUE READING
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