A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components.

@article{Henningsson2006ARF,
  title={A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components.},
  author={Frida Henningsson and Sonja Patricia Hergeth and Robert Cortelius and Magnus {\AA}brink and Gunnar Pejler},
  journal={The FEBS journal},
  year={2006},
  volume={273 21},
  pages={
          4901-12
        }
}
In the absence of serglycin proteoglycans, connective tissue-type mast cells fail to assemble mature metachromatic secretory granules, and this is accompanied by a markedly reduced ability to store neutral proteases. However, the mechanisms behind these phenomena are not known. In this study, we addressed these issues by studying the functionality and morphology of secretory granules as well as the fate of the secretory granule proteases in bone marrow-derived mast cells from serglycin(+/+) and… CONTINUE READING

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