A role for reverse transcripts in gene conversion
@article{Derr1993ARF, title={A role for reverse transcripts in gene conversion}, author={L. K. Derr and J. Strathern}, journal={Nature}, year={1993}, volume={361}, pages={170-173} }
RECOMBINATION between a diffusible reverse transcript and its homologous chromosomal allele has been proposed as a mechanism for the precise removal of introns from DNA and gene conversion of dispersed repeated sequences1,2. We have reported that RNA-mediated recombination occurs in the yeast Saccharomyces cerevisiae3. This recombination requires expression of the retrotransposon Ty, and results in intron loss from a plasmid-borne marker gene and the formation of pseudogenes. Because the… CONTINUE READING
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