A role for reverse transcripts in gene conversion

@article{Derr1993ARF,
  title={A role for reverse transcripts in gene conversion},
  author={L. K. Derr and J. Strathern},
  journal={Nature},
  year={1993},
  volume={361},
  pages={170-173}
}
  • L. K. Derr, J. Strathern
  • Published 1993
  • Biology, Medicine
  • Nature
  • RECOMBINATION between a diffusible reverse transcript and its homologous chromosomal allele has been proposed as a mechanism for the precise removal of introns from DNA and gene conversion of dispersed repeated sequences1,2. We have reported that RNA-mediated recombination occurs in the yeast Saccharomyces cerevisiae3. This recombination requires expression of the retrotransposon Ty, and results in intron loss from a plasmid-borne marker gene and the formation of pseudogenes. Because the… CONTINUE READING
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