A role for recombination junctions in the segregation of mitochondrial DNA in yeast

@article{Lockshon1995ARF,
  title={A role for recombination junctions in the segregation of mitochondrial DNA in yeast},
  author={Daniel Lockshon and Stephan G Zweifel and Lisa L Freeman-Cook and Heather E Lorimer and Bonita J. Brewer and Walton L. Fangman},
  journal={Cell},
  year={1995},
  volume={81},
  pages={947-955}
}
In S. cerevisiae, mitochondrial DNA (mtDNA) molecules, in spite of their high copy number, segregate as if there were a small number of heritable units. The rapid segregation of mitochondrial genomes can be analyzed using mtDNA deletion variants. These small, amplified genomes segregate preferentially from mixed zygotes relative to wild-type mtDNA. This segregation advantage is abolished by mutations in a gene, MGT1, that encodes a recombination junction-resolving enzyme. We show here that… CONTINUE READING

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