A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes.

@article{Hill1999ARF,
  title={A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes.},
  author={Michelle M. Hill and Sharon F. Clark and David F. Tucker and Morris J Birnbaum and David E. James and S Lance Macaulay},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 11},
  pages={
          7771-81
        }
}
Insulin stimulates glucose uptake into muscle and fat cells by promoting the translocation of glucose transporter 4 (GLUT4) to the cell surface. Phosphatidylinositide 3-kinase (PI3K) has been implicated in this process. However, the involvement of protein kinase B (PKB)/Akt, a downstream target of PI3K in regulation of GLUT4 translocation, has been controversial. Here we report that microinjection of a PKB substrate peptide or an antibody to PKB inhibited insulin-stimulated GLUT4 translocation… CONTINUE READING
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