A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature.

@article{CarvalhoTavares2000ARF,
  title={A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature.},
  author={Juliana Carvalho-Tavares and Michael J Hickey and Jamie Hutchison and Jean Michaud and Ian T. Sutcliffe and Paul Kubes},
  journal={Circulation research},
  year={2000},
  volume={87 12},
  pages={1141-8}
}
The mechanisms mediating leukocyte recruitment into the cerebral nervous system during inflammation are still poorly understood. The objective of this study was to investigate the leukocyte recruitment in the brain microcirculation by intravital microscopy. Superfusion of the brain with artificial cerebrospinal fluid did not induce leukocyte rolling or adhesion. However, intraperitoneal tumor necrosis factor-alpha (TNF-alpha) caused marked leukocyte rolling and adhesion in the brain… CONTINUE READING