A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila.

@article{Jaffe1997ARF,
  title={A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila.},
  author={Leah Jaffe and Hyung Don Ryoo and Richard S. Mann},
  journal={Genes \& development},
  year={1997},
  volume={11 10},
  pages={
          1327-40
        }
}
We present evidence that the in vivo activity of the HOX protein Antennapedia (ANTP) is modified because of phosphorylation by the serine/threonine kinase casein kinase II (CKII). Using an in vivo assay a form of ANTP that has alanine substitutions at its CKII target sites has, in addition to wild-type ANTP functions, the ability to alter severely thoracic and abdominal development. The novel functions of this protein suggest that this form of ANTP is not suppressed phenotypically by the more… Expand
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