A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease.

@article{Marwick2010ARF,
  title={A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease.},
  author={John A. Marwick and Gaetano Caramori and Paolo Casolari and Federico Mazzoni and Paul A. Kirkham and Ian M. Adcock and Kian Fan Chung and Alberto Papi},
  journal={The Journal of allergy and clinical immunology},
  year={2010},
  volume={125 5},
  pages={1146-53}
}
BACKGROUND Glucocorticoid function is markedly impaired in the lungs of patients with chronic obstructive pulmonary disease (COPD). This reduction in glucocorticoid sensitivity might be due to an oxidant-mediated increase in phosphoinositol 3-kinase (PI3K) delta signaling. OBJECTIVE We sought to determine the role of PI3Kdelta in the reduced… CONTINUE READING