A role for p75 receptor in neurotrophin-3 functioning during the development of limb proprioception.

Abstract

Neurotrophin-3 is indispensable for the development of limb proprioceptive neurons and their end organs, muscle spindles. To determine whether the low-affinity p75 receptor potentiates the actions of neurotrophin-3, we examined the development of the proprioceptive system in p75 null mutant mice that had either normal or decreased tissue levels of… (More)

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