A role for oxytocin and 5-HT1A receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine (“ecstasy”)

@article{Thompson2007ARF,
  title={A role for oxytocin and 5-HT1A receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine (“ecstasy”)},
  author={M. R. Thompson and P. Callaghan and G. Hunt and J. Cornish and I. McGregor},
  journal={Neuroscience},
  year={2007},
  volume={146},
  pages={509-514}
}
The drug 3,4 methylenedioxymethamphetamine (MDMA; ecstasy) has a widely documented ability to increase feelings of love and closeness toward others. The present study investigated whether oxytocin, a neuropeptide involved in affiliative behavior, may play a role in this effect. A moderate (5 mg/kg, i.p.) dose of MDMA increased social interaction in male Wistar rats, primarily by increasing the amount of time rats spent lying adjacent to each other. MDMA (5 mg/kg) activated oxytocin-containing… Expand
MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635
TLDR
Results indicate that MDMA's action on oxytocin producing cells in the hypothalamus is mediated through 5-HT(1A) receptors and that certain specific cortical, limbic and brainstem sites are also activated by MDMA via these receptors. Expand
Examining the role of oxytocin in the interoceptive effects of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) using a drug discrimination paradigm in the rat
TLDR
The results of this study implicate oxytocin receptor activation as a key MDMA‐specific interoceptive cue in male and female rats and support the conclusion that this is one of the features of MDMA's subjective effects that distinguishes it from AMP. Expand
Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the V1A Receptor
TLDR
Results show for the first time acute prosocial effects of peripherally injected OT and AVP in laboratory rats, and suggest a commonality of action of OT, AVP, and MDMA in stimulating social behavior that involves V1ARs. Expand
MDMA (‘Ecstasy’), oxytocin and vasopressin modulate social preference in rats: A role for handling and oxytocin receptors
TLDR
Results further confirm prosocial actions of MDMA, OT and AVP, which are dependent on handling history and indicate that social preference is sensitive to OTR rather than V1AR modulation. Expand
The Non-Peptide Arginine-Vasopressin v1a Selective Receptor Antagonist, SR49059, Blocks the Rewarding, Prosocial, and Anxiolytic Effects of 3,4-Methylenedioxymethamphetamine and Its Derivatives in Zebra Fish
TLDR
Findings show that the OT/vasopressin system is involved in the rewarding, prosocial, and anxiolytic effects of MDMA, DOB, and PMA in zebra fish and underline the association between this system and the behavioral alterations associated with disorders related to substance abuse. Expand
Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA (“Ecstasy”) in Rats and Preserves Affinity for the Serotonin Transporter (SERT)
TLDR
2-Br-4,5-MDMA lacks all key MDMA-like behavioral responses in rats, including hyperlocomotion, enhanced active avoidance conditioning responses and increased social interaction, indicating that aromatic bromination at C(2) modulates the pharmacodynamic properties of the substrate MDMA, yielding a citalopram-like compound. Expand
Effects of ±3,4-Methylenedioxymethamphetamine (MDMA) Administration on Social Emotional Processing in Humans
Ecstasy users report that the drug produces feelings of increased empathy and sociability [1]. Such ‘empathogenic’ effects are thought to motivate recreational use of ecstasy [2]. In addition, theExpand
3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner
TLDR
Nonhuman primates show MDMA-specific increases in affiliative social behaviors following MDMA administration, in concordance with human and rodent studies, and MDMA-induced increases in social behaviors are 5-HT2A, but not 5- HT1A, receptor dependent. Expand
Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration
TLDR
MDMA induces oxytocin release in humans, which may be involved in the characteristic prosocial effects of ecstasy, in a double blind, randomized, crossover, and placebo-controlled study in 15 healthy volunteers. Expand
Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA
TLDR
The findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 24 REFERENCES
Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat
TLDR
Results indicate that prosocial effect of MDMA may involve 5-HT 1A and possibly5-HT 2B/2C receptors and in contrast, MDMA-induced generalised anxiety, as measured by the emergence test, seems unlikely to involve the 5-ht 1A, 5- HT 1B or 5-Hat 2A,5- HT 2B or 6-HT2B receptors. Expand
The distribution of 3,4-methylenedioxymethamphetamine “Ecstasy”-induced c-fos expression in rat brain
TLDR
The widespread distribution of 3,4-methylenedioxymethamphetamine-induced c-fos expression seen in this study can be linked to the profound alterations in physiological function, mood and behaviour produced by this drug. Expand
The effect of 3,4‐methylenedioxymethamphetamine (MDMA, ?ecstasy?) and its metabolites on neurohypophysial hormone release from the isolated rat hypothalamus
TLDR
MDMA and its metabolites can stimulate both oxytocin and vasopressin release in vitro, the response being dose dependent for each drug with HMMA being the most potent. Expand
Anxiolytic effect of the 5-HT1A compounds 8-hydroxy-2-(di-n-propylamino) tetralin and ipsapirone in the social interaction paradigm: Evidence of a presynaptic action
TLDR
Data strongly suggest that both 5-HT1A ligands act presynaptically to reduce the anxiety levels in the social interaction paradigm. Expand
(+/-)-3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') increases social interaction in rats.
TLDR
The results indicate that MDMA has both anxiogenic and anxiolytic effects depending upon the test situation employed, and the facilitation of social interaction produced by MDMA in rats concurs with human experience of MDMA as a uniquely prosocial drug. Expand
Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats.
TLDR
In rats tested in the social interaction paradigm, greater prosocial effects of MDMA were seen at a hot temperature (30 degrees C) relative to normal laboratory temperature (21 degrees C). Expand
WAY-100635 inhibits 8-OH-DPAT-stimulated oxytocin, ACTH and corticosterone, but not prolactin secretion.
TLDR
8-OH-DPAT stimulates oxytocin, ACTH, and corticosterone but not prolactin secretion via activation of5-HT1A receptors and blockade of 5-HT2A receptors may unmask 8-OH -DPAT simulation of renin secretion through non-5- HT1A receptor mechanisms. Expand
High ambient temperature increases 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)-induced Fos expression in a region-specific manner
TLDR
Results indicate that high temperatures accentuate key neural effects of MDMA and this may help explain the widespread use of the drug under hot conditions at dance parties as well as the more hazardous nature of MDMA taken under such conditions. Expand
Psychological and Cardiovascular Effects and Short-Term Sequelae of MDMA (“Ecstasy”) in MDMA-Naïve Healthy Volunteers
TLDR
The present findings are consistent with the hypothesis that MDMA produces a different psychological profile than classic hallucinogens or psychostimulants. Expand
Vasopressin and oxytocin as neurohormonal mediators of MDMA (ecstasy) sociosexual behavioural effects.
TLDR
It is proposed that the sense of empathy, emotional intimacy and sexual arousal that ec-stasy may enhance could be related to the re-lease of ‘‘prosocial’’ molecules such as AVP and OXT into the systemic circulation. Expand
...
1
2
3
...