A role for nuclear phospholipase Cbeta 1 in cell cycle control.

  title={A role for nuclear phospholipase Cbeta 1 in cell cycle control.},
  author={Irene Faenza and Alessandro Matteucci and Lucia Manzoli and Anna Maria Billi and Michela Aluigi and Daniela Peruzzi and Marco Vitale and Sergio Castorina and Pann Ghill Suh and Lucio Cocco},
  journal={The Journal of biological chemistry},
  volume={275 39},
Phosphoinositide signaling resides in the nucleus, and among the enzymes of the cycle, phospholipase C (PLC) appears as the key element both in Saccharomyces cerevisiae and in mammalian cells. The yeast PLC pathway produces multiple inositol polyphosphates that modulate distinct nuclear processes. The mammalian PLCbeta(1), which localizes in the nucleus, is activated in insulin-like growth factor 1-mediated mitogenesis and undergoes down-regulation during murine erythroleukemia differentiation… CONTINUE READING