A role for nuclear factor kappaB in the antiapoptotic function of insulin.

@article{Bertrand1998ARF,
  title={A role for nuclear factor kappaB in the antiapoptotic function of insulin.},
  author={Françoise Bertrand and Azzedine Atfi and Axelle Cadoret and Gilles L'Allemain and H{\'e}l{\`e}ne Robin and Olivier Lascols and Jacqueline Capeau and Gis{\'e}le Cherqui},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 5},
  pages={
          2931-8
        }
}
We previously reported that insulin activates nuclear factor kappaB (NF-kappaB) in Chinese hamster ovary (CHO)-R cells overexpressing wild-type insulin receptors (IRs) through a pathway requiring IR tyrosine kinase and Raf-1 kinase activities. We now investigated whether the activation of NF-kappaB by insulin could serve an antiapoptotic function. Insulin (10(-9)-10(-7) M) inhibited apoptosis induced by serum withdrawal in CHO-R cells in a concentration-dependent manner. Insulin antiapoptotic… CONTINUE READING

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