A role for neuropeptide Y Y5 but not the Y1-receptor subtype in food deprivation-induced reinstatement of heroin seeking in the rat

@article{Maric2011ARF,
  title={A role for neuropeptide Y Y5 but not the Y1-receptor subtype in food deprivation-induced reinstatement of heroin seeking in the rat},
  author={Tia Maric and Firas Sedki and Danielle Chafetz and Nick Schoela and Uri Shalev},
  journal={Psychopharmacology},
  year={2011},
  volume={218},
  pages={693-701}
}

• Tia Maric, Firas Sedki, +2 authors Uri Shalev
• Published in Psychopharmacology 2011
• DOI:10.1007/s00213-011-2362-9

Rational and objectivesNeuropeptide Y (NPY), an orexigenic peptide that is released during periods of food restriction, has been shown to have a significant modulatory impact on drug-related behaviors. We have previously reported that both acute food deprivation (FD) and NPY injections can reinstate extinguished drug-seeking behavior, a proposed animal model of relapse to drug abuse. However, it is not clear whether the FD effect on drug seeking is dependent on NPY transmission. Here, we used… CONTINUE READING

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