A role for neuropeptide Y Y5 but not the Y1-receptor subtype in food deprivation-induced reinstatement of heroin seeking in the rat

@article{Maric2011ARF,
  title={A role for neuropeptide Y Y5 but not the Y1-receptor subtype in food deprivation-induced reinstatement of heroin seeking in the rat},
  author={Tia Maric and Firas Sedki and Danielle Chafetz and Nick Schoela and Uri Shalev},
  journal={Psychopharmacology},
  year={2011},
  volume={218},
  pages={693-701}
}
Rational and objectivesNeuropeptide Y (NPY), an orexigenic peptide that is released during periods of food restriction, has been shown to have a significant modulatory impact on drug-related behaviors. We have previously reported that both acute food deprivation (FD) and NPY injections can reinstate extinguished drug-seeking behavior, a proposed animal model of relapse to drug abuse. However, it is not clear whether the FD effect on drug seeking is dependent on NPY transmission. Here, we used… 
A limited role for ghrelin in heroin self‐administration and food deprivation‐induced reinstatement of heroin seeking in rats
TLDR
The results suggest that signals mediated through ghrelin receptors play a limited role in FD‐induced augmentation of heroin reinforcement and reinstatement of extinguished heroin seeking.
The Identification of Neuropeptide Y Receptor Subtype Involved in Phenylpropanolamine-induced Increase in Oxidative Stress and Appetite Suppression
TLDR
Results provide molecular mechanism of NPY-mediated PPA anorexia and may aid the understanding of the toxicology of PPA.
Effects of drugs of abuse on the central neuropeptide Y system
TLDR
Manipulation of the NPY system seems to be a potential target to counteract neural alterations, addiction‐related behaviors and cognitive deficits induced by these drugs.
The Effects of Mu and Kappa Opioid Antagonists on Reinstatement of Sugar Seeking
TLDR
Data confirm the critical role of opioid systems in sugar consumption and sugar seeking, further demonstrate the clinical relevance of using mu-opioid antagonists to treat problematic eating and warrant further investigation of a role for kappa opioid receptors in feeding related behaviour.
Relapse to opioid seeking in rat models: behavior, pharmacology and circuits
TLDR
Pharmacological and circuit mechanisms of opioid seeking, as assessed in the classical extinction-reinstatement model, are discussed, including the phenomenon of “incubation of heroin craving” (the time-dependent increases in heroin seeking during abstinence).
Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress
TLDR
The phenomenon of stress-induced reinstatement, first shown with an intermittent footshock stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including cocaine, methamphetamine, nicotine, and alcohol, and is also observed in the conditioned place preference model in rats and mice.
...
...

References

SHOWING 1-10 OF 56 REFERENCES
A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats.
TLDR
The results suggest that acute food deprivation-induced reinstatement of heroin seeking in rats may be mediated, at least in part, by activation of the dopamine D1-like receptor.
A role for corticotropin-releasing factor, but not corticosterone, in acute food-deprivation-induced reinstatement of heroin seeking in rats
TLDR
The present data suggest that, as demonstrated for footshock-induced reinstatement of drug seeking, brain CRF, but not corticosterone, plays a critical role in acute food-deprivation-induced Reinstatement of heroin seeking.
Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats.
TLDR
The data indicate that NPY5RA-972 is a potent, selective, orally active, and CNS-penetrant antagonist of the NPY Y5 receptor that prevents feeding driven by activation of this receptor.
Neuropeptide Y attenuates naloxone-precipitated morphine withdrawal via Y5-like receptors.
TLDR
The pharmacological profile suggests that the antiwithdrawal effect of NPY is mediated via the recently cloned Y5 receptor, consistent with a potential role for NPY and Y5-like receptors in basic mechanisms and as a therapeutic target in opioid dependence and withdrawal.
Neuropeptide Y Y1 receptor antagonist BIBP3226 produces conditioned place aversion in rats
Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats
TLDR
Results indicate that activation of alpha-2 adrencoceptor agonists is involved in both stress-induced reinstatement of alcohol seeking and alcohol self-administration, and should be considered in the treatment of alcohol dependence.
...
...