A role for neural cell adhesion molecule in the formation of the avian inner ear.

@article{Brown1998ARF,
  title={A role for neural cell adhesion molecule in the formation of the avian inner ear.},
  author={J. W. Brown and E Beck-Jefferson and S. Robert Hilfer},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1998},
  volume={213 4},
  pages={359-69}
}
The inner ear forms by a series of folds within an ectodermal placode. Previous work has shown that changes in surrounding tissues play a more prominent role in invagination than changes in the cytoskeleton of the primordium. Interference with the integrity of the extracellular matrix causes abnormalities in the folding process, primarily related to abnormalities in the paraxial mesoderm which lies ventral to the placode. In this study, the role of the neural cell adhesion molecule (N-CAM) was… CONTINUE READING