A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion.

@article{Sohn2009ARF,
  title={A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion.},
  author={Regina Lee Sohn and Ping Huang and Genri Kawahara and Matthew G. E. Mitchell and Jeffrey R. Guyon and Raghu Kalluri and Louis M. Kunkel and Emanuela Gussoni},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 23},
  pages={
          9274-9
        }
}
Skeletal muscle is formed via fusion of myoblasts, a well-studied process in Drosophila. In vertebrates however, this process is less well understood, and whether there is evolutionary conservation with the proteins studied in flies is under investigation. Sticks and stones (Sns), a cell surface protein found on Drosophila myoblasts, has structural homology to nephrin. Nephrin is a protein expressed in kidney that is part of the filtration barrier formed by podocytes. No previous study has… CONTINUE READING

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