A role for midline closure in the reestablishment of dorsoventral pattern following dorsal hindbrain ablation.

@article{Buxton1997ARF,
  title={A role for midline closure in the reestablishment of dorsoventral pattern following dorsal hindbrain ablation.},
  author={Paul G Buxton and Paul N. Hunt and Patrizia Ferretti and Peter Thorogood},
  journal={Developmental biology},
  year={1997},
  volume={183 2},
  pages={
          150-65
        }
}
The cellular and molecular study of dorsal neural tube ablation reported here demonstrates a critical role for midline closure in hindbrain repatterning. This was revealed by detailed analysis of the transcriptional response of two genes, Pax-3 and slug, during repair of the neural tube following ablation. The reexpression of Pax-3 appears to rely on a single surface ectoderm/neuroepithelial contact, while this is insufficient for reexpression of slug. In fact, slug up-regulation only occurred… CONTINUE READING

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