A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton.

@article{Akasaka1996ARF,
  title={A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton.},
  author={Takeshi Akasaka and Masamoto Kanno and Rudi Balling and M A Mieza and Masaru Taniguchi and Haruhiko Koseki},
  journal={Development},
  year={1996},
  volume={122 5},
  pages={1513-22}
}
Segment identity in both invertebrates and vertebrates is conferred by spatially restricted distribution of homeotic gene products. In Drosophila, the expression of Homeobox genes during embryogenesis is initially induced by segmentation gene products and then maintained by Polycomb group and Trithorax group gene products. Polycomb group gene homologs are conserved in vertebrates. Murine mel-18 and closely related bmi-1 are homologous to posterior sex combs and suppressor two of zeste. Mel-18… CONTINUE READING

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