A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

  title={A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection},
  author={Hiroshi Suzuki and Yukiko Kurihara and Motohiro Takeya and Nobuo Kamada and Motoyukl Kataoka and Kouichi Jishage and Otoya Ueda and Hisashl Sakaguchi and Takayuki Higashi and Tsukasa Suzuki and Yoshiaki Takashima and Yoshiki Kawabe and Osamu Cynshi and Youichiro Wada and Makoto Honda and Hiroki Kurihara and Hiroyuki Aburatani and Takefumi Doi and Akiyo Matsumoto and Sadahiro Azuma and Tetsuo Noda and Yutaka Toyoda and H Itakura and Yoshio Yazaki and Seikoh Horiuchi and Kiyoshi Takahashi and Johan Kar Kruijt and Theo J. C. van Berkel and Urs P. Steinbrecher and Shun Ishibashi and Nobuyo N. Maeda and Siamon Gordon and Tatsuhiko Kodama},
Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL)1–6. MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens7, and also mediates cation-independent macrophage adhesion in vitro8. Here we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of… CONTINUE READING
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