A role for lymphotoxin in the acquisition of Ly49 receptors during NK cell development.

@article{Lian2004ARF,
  title={A role for lymphotoxin in the acquisition of Ly49 receptors during NK cell development.},
  author={Rebecca H. Lian and Robert K. Chin and Hajnalka E Nemeth and Shon L Libby and Yang-Xin Fu and Vinay Kumar},
  journal={European journal of immunology},
  year={2004},
  volume={34 10},
  pages={2699-707}
}
NK cells lyse tumor, virus-infected and allogeneic cells through a recognition system involving inhibitory and activating receptors, among which are the Ly49 molecules that recognize MHC class I proteins. To date, little is known about the regulation of Ly49 expression during NK cell development. In this study we report that the acquisition of Ly49 receptors by NK cells is significantly reduced in lymphotoxin (LT) alpha-deficient mice, whereas it is increased in LTalpha transgenic mice… CONTINUE READING

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The regulation of NK cell function and development.

Frontiers in bioscience : a journal and virtual library • 2008

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