A role for lateral hypothalamic orexin neurons in reward seeking

@article{Harris2005ARF,
  title={A role for lateral hypothalamic orexin neurons in reward seeking},
  author={G. Harris and M. Wimmer and G. Aston-Jones},
  journal={Nature},
  year={2005},
  volume={437},
  pages={556-559}
}
The lateral hypothalamus is a brain region historically implicated in reward and motivation, but the identity of the neurotransmitters involved are unknown. The orexins (or hypocretins) are neuropeptides recently identified as neurotransmitters in lateral hypothalamus neurons. Although knockout and transgenic overexpression studies have implicated orexin neurons in arousal and sleep, these cells also project to reward-associated brain regions, including the nucleus accumbens and ventral… Expand
1,078 Citations
Role of lateral hypothalamic orexin neurons in reward processing and addiction
  • 259
  • Highly Influenced
  • PDF
Role of lateral hypothalamus in two aspects of attention in associative learning
  • 18
Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction
  • 318
  • Highly Influenced
A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference
  • 86
  • Highly Influenced
  • PDF
Afferents to the orexin neurons of the rat brain
  • 511
Arousal and reward: a dichotomy in orexin function
  • 483
  • PDF
Lateral Hypothalamic Control of the Ventral Tegmental Area: Reward Evaluation and the Driving of Motivated Behavior
  • 35
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
Differential expression of orexin receptors 1 and 2 in the rat brain
  • 1,345
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
  • 2,920
  • PDF
...
1
2
3
4
...