A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomas.

@article{Marches2001ARF,
  title={A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomas.},
  author={Radu Marches and Ellen S. Vitetta and Jonathan W. Uhr},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 6},
  pages={3434-9}
}
We show that anti-IgM-induced cell death in a human B lymphoma cell line, B104, is associated with early intracellular acidification and cell shrinkage. In contrast, another human B cell lymphoma line, Daudi, less susceptible to B cell antigen receptor-mediated cell death, responded to anti-IgM with an early increase in intracellular pH (pH(i)). The anti-IgM-induced changes of pH(i) were associated with different levels of activation of the Na(+)/H(+) exchanger isoform 1 (NHE1) as judged by its… CONTINUE READING

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