A role for interferon regulatory factor 4 in receptor editing.

@article{Pathak2008ARF,
  title={A role for interferon regulatory factor 4 in receptor editing.},
  author={Simanta Pathak and Shibin Ma and Long N Trinh and Runqing Lu},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 8},
  pages={
          2815-24
        }
}
Receptor editing is the primary means through which B cells revise antigen receptors and maintain central tolerance. Previous studies have demonstrated that interferon regulatory factor 4 (IRF-4) and IRF-8 promote immunoglobulin light-chain rearrangement and transcription at the pre-B stage. Here, the roles of IRF-4 and -8 in receptor editing were analyzed. Our results show that secondary rearrangement was impaired in IRF-4 but not IRF-8 mutant mice, suggesting that receptor editing is… CONTINUE READING
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