A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.

@article{Lucchinetti2002ARF,
  title={A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.},
  author={Claudia F. Lucchinetti and Raul N Mandler and Dorian B. McGavern and Wolfgang Bruck and Gerald J. Gleich and Richard M. Ransohoff and Corinna Trebst and Brian G. Weinshenker and Dean M. Wingerchuk and Joseph E. Parisi and Hans Lassmann},
  journal={Brain : a journal of neurology},
  year={2002},
  volume={125 Pt 7},
  pages={
          1450-61
        }
}
Devic's disease [neuromyelitis optica (NMO)] is an idiopathic inflammatory demyelinating disease of the CNS, characterized by attacks of optic neuritis and myelitis. The mechanisms that result in selective localization of inflammatory demyelinating lesions to the optic nerves and spinal cord are unknown. Serological and clinical evidence of B cell autoimmunity has been observed in a high proportion of patients with NMO. The purpose of this study was to investigate the importance of humoral… 

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