A role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesis.

@article{Freimanis2010ARF,
  title={A role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesis.},
  author={G Freimanis and Paul Hooley and Hora Davari Ejtehadi and Hassan Abdellah Ahmed Ali and Alistair C. Veitch and Paul B Rylance and Arash Alawi and John S. Axford and Alan M Nevill and Paul Gerard Murray and Paul N Nelson},
  journal={Clinical and experimental immunology},
  year={2010},
  volume={160 3},
  pages={340-7}
}
Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections within the human genome. These molecular fossils draw parallels with present-day exogenous retroviruses and have been linked previously with immunopathology within rheumatoid arthritis (RA). Mechanisms of pathogenesis for HERV-K in RA such as molecular mimicry were investigated. To clarify a role for HERVs in RA, potential autoantigens implicated in autoimmunity were scanned for sequence identity with retroviral… CONTINUE READING